Endocrine Abstracts

Background: Duration of postoperative follow-up in patients with pheochromocytoma/paraganglioma (PPGL) is still not clearly specified. It is estimated that 5-year risk of a new events (metastatic/recurrent disease) after surgery is 27% in young patients, 25% in those with paraganglioma and around 10% in older patients and those with pheochromocytoma. Arterial aneurysms (AA) accompanying PPGL are described as complication/comorbidity that affects prognosis in these patients.</p...

Background: Several stimulatory tests for differential diagnosis of ACTH dependent Cushing’s syndrome are avilable, CRH being the most valuable test in patients with Cushing’s disease (CD). Exaggerated responses to ghrelin have also been shown in patients with CD mainly due to overexpression of GHS receptors on corticotrope tumor cells. However, the effects of combined stimulation with CRH+ghrelin on ACTH and cortisol secretion have not been tested before in these pa...

The short-term results of transsphenoidal surgery as initial treatment for acromegaly were analyzed according to consensus defining the criteria for cure of acromegaly.Thirty nine newly diagnosed patients with acromegaly (20 females and 19 males, mean age 46.9 plus/minus 1.4 years, range 29-66 yrs), underwent transsphenoidal pituitary adenomectomy by the same neursurgeon. Patients have been assessed postoperatively at 8 weeks (GH after 75 g oral glucose ...

Kisspeptin produced by placenta is involved in the regulation of early placental development. Aberrant placental development and placental dysfunction are common in pregnancies with diabetes and hypertension. Parameters of fetal growth, feto-placental circulation, pregnancy outcome, placental weight and morphology were recorded and correlated with kisspeptin levels in pregnant women with diabetes (chronic insulin dependent-IDDM and gestational-GD) and hypertension (chronic-H, ...

Introduction: Several studies have shown that cortisol and altered HPA axis activity may participate in pathogenesis and severity of coronary artery disease (CAD).Aim: To examine possible interaction between cortisol secretion and HPA axis activity with severity of CAD.Patients and methods: Diurnal cortisol secretion and dexamethasone suppression test (DST) were analyzed in 200 consecutive patients (mean age 59.3±8.6) referred...